 Just to introduce myself, I'm a child neurologist. I'm currently doing PhD in neuro-inflammation in developing biomarkers of neuro-inflammation under the supervision of Professor Russell Dale. I'm very grateful and humbled to have been awarded Brain Foundation grant, which will help me continue my further research. So, torrid syndrome, obsessive-compulsive disorder, autism are very common disorders affecting one in 50 to 200 children, people. And these are often seen together and they manifest with behavior problems, concentration difficulties, and affect the cause-learning impairment, affect day-to-day functioning of children and the families with these problems. And recently, in recent UK Health Economic Assessment has shown that the OCD and autism have been defined as the two of the top 10 economical costly diseases to the society. And number of factors have been proposed as ideological reasons, including the environmental, genetic and immune mechanisms. And over the last 10 years, there has been increasing literature on the role of immune activation in these disorders. And our clinical experience tells us that in a subgroup of these patients with obsessive-compulsive disorder, ticks as well as autism, they respond to immune treatment. And despite the reported immunological abnormalities and despite the benefits of immune treatment, unfortunately we do not have any biomarkers to diagnose inflammation and treat and monitor these patients. And so with the support from the Brain Foundation, so we're trying to propose a study where we will be collecting the clinical details as well as treatment response of these children who present with the combination of the autism spectrum disorder, the obsessive-compulsive disorder and torrid syndrome. And we will be, especially those who have fluctuating course of clinical relapses and remissions where immune mechanisms may be playing a role. And we would be measuring the spinal fluid levels of immune molecules called cytokines, chemokines, as well which will help us identify immune response. And also we will measure the molecules of neuronal glial markers, which will help us understand the, determine the extent of the tissue injury in these patients. So through this study, we hope that we will identify treatable forms of immune-mediated ticks or obsessive-compulsive disorders in autism. And we will be able to describe the clinical phenotype and treatment response in these children. And the cytokine, chemokine profiling, it will help us provide new insights into these disorders which have poorly understood immune-mediated pathogenesis. And it will also help us diagnose and monitor inflammation, extent of injury and monitor response to treatment. And hopefully with improved understanding of immune response mechanisms, it will help develop new treatment strategies in the future. And again, I would like to thank Brain Foundation for their support which would help me continue with my research in this sector.