 Metal compounds are essential for the health of living organisms, and when they become unbalanced, it can lead to various diseases. Today, transition metals are being used in pharmaceuticals as diagnostics and treatments due to their unique ability to alter the properties of molecules compared to organic molecules. This has led to increased research into metal drug complexes, with many approaches being developed to characterize, activate, deliver and understand the underlying mechanisms. By integrating these different approaches, such as chemoproteomics, nanoparticles, and activation strategies, we can gain a better understanding of how cells respond to metal drugs, which could be the foundation for developing new drugs or modifying existing ones. This article was authored by Alaria Yacobuchi, Sarah LaManna, Irene Cipolloni, and others.