 This study aims to assess the effectiveness of melanoma surveillance photography, MSP, as a tool for reducing the number of unnecessary biopsies among people who are at high risk of developing melanoma. MSP involves taking two or three-dimensional total body photographs with tagged digital dermoscopy, which can detect suspicious lesions that may be missed by visual inspection alone. The study will compare the number of unnecessary biopsies between those who undergo MSP and those who do not, while also evaluating the cost-effectiveness and acceptability of this approach. This article was authored by Mabel Kay Yang, Annie Kust, H. Peter Sawyer, and others.