 This study found that wildfire-generated PM2.5 is associated with increasing COVID-19 incidents, mortality, and severity in five Brazilian Amazon states with high records of wildfires from 2020 to 2021. The states of Para, Maddo Grosso, and Amazonas reported the highest values of overall cases, deaths, and severe cases. The study also found that the growth in PM2.5 concentrations was higher in Maddo Grosso, with an increase of 24.4%, followed by Rondonia, 14.9%. The risk of COVID-19 morbidity and mortality is nearly two times higher among individuals exposed to high concentrations of PM2.5, and the attributable fraction to PM2.5 in the studied area represents an important role in the risk associated with COVID-19 in the Brazilian Amazon region. This article was authored by Karen Dos Santos-Goncalves, Blober G. Serrino, Marcelo Oliveira de Costa, and others. We are article.tv, links in the description below.