 This study examined the genetics and epigenetics of clear cell renal cell carcinomas to identify tumor-specific markers and gain insight into the underlying mechanisms of tumoragesis. The researchers used multiple amic approaches including RNA sequencing, ATAC sequencing, and proteomic profiling to identify 20 tumor-specific markers. They found that one marker, cerulopasmin, was associated with poorer prognosis. Additionally, they observed intratumoral heterogeneity in terms of inflammatory NEMT signatures. Furthermore, they identified differences in chromatin accessibility between tumors with different mutations in BAP1 or PBRM1. This study provides valuable insights into the molecular mechanisms of clear cell renal cell carcinoma tumoragesis. This article was authored by Yij Wu, Nadeshda V. Terakanova, Wagma Karavan, and others.