 This study investigated the antimicrobial properties of seven different materials composed of silica mesoporous nanoparticles, SMNs, modified with fluoroquinolone drugs, copper or silver ions, and phenytoin sodium. The SMNs were found to be effective at killing both gram-positive and gram-negative bacteria, as well as multi-drug-resistant strains of staphylococcus aureus and pseudomonas aeroginosa. Additionally, the materials were able to reduce biofilm formation and inhibit bacterial growth in a wound-like environment. This suggests that these materials could be used for the prevention and treatment of infected wounds. This article was authored by Maitre Yu-Galdir Baizu, John Hiro Aguilera Correa, Iter San Sebastian and others.