 This review provides a critical assessment of silver nanoparticle toxicity, highlighting the challenges in understanding their mechanisms of interaction and modes of action due to factors such as particle size, shape, surface coating, and evolution. The authors emphasize the need for detailed descriptions of these factors in future studies to assess the environmental and biological impacts of silver nanoparticles. They also raise concerns about overuse of nanosilver and potential bacterial resistance. The review concludes with a call for a risk-benefit analysis for all applications of silver nanoparticles and eventually restrictions on their use where a clear benefit cannot be demonstrated. This article was authored by Assault Lynch, Kenneth A Dawson, Andreas Lutch, and others. We are article.tv, links in the description below.