 The study reports the fabrication and evaluation of zinc oxide or silver nanoparticles capped with vitamin A or E-nanocomposite that were incorporated in weak gluten films for burn-wound treatment. The results show that the NPS vitamin composite-loaded WG films have significant antioxidant and antibacterial potential, promote wound contraction, re-epithelialization, collaging deposition with fibroblast regeneration, adipocytes, and hair follicle development in vivo. The biocompatible nature and biodegradable potential make the films a promising solution for burn-wound healing management. This article was authored by Nneela Sajat, Hussain Ali, and Muhammad Zia.