 This review summarizes recent advances in the anti-cancer activities of natural products derived from Chinese herbal medicine, including compounds such as curcumin, epiglokatikin galate, anutymisonin, and highlights their pharmacological effects, mechanism of action, clinical studies, and potential applications in combined therapy and immunomodulation. The review also extends to describe other promising compounds and the need for further research on their immunoregulatory effects and mechanisms of action as modulators of immune checkpoints. This article was authored by Huoluo, Kai-tim Wong, Hanbin Chen, and others.