 So at the moment, the options are very limited. There are no cures for lupus and most of the treatments that exist at the moment still fail to treat the most severe manifestations. Autoimmune diseases are a global problem that affects 5% of the population so we have placed very strong emphasis in setting up a large international network. The Center for Personalized Immunology has a very large network of clinicians that contribute patients with very extreme cases of immune diseases and this is a very powerful sample set for the researchers to work with to understand how these diseases work. We work with clinicians from countries including Spain, Germany, the southeastern European countries like Macedonia and Croatia, the Middle East including Oman and Turkey. We've got samples from some South American countries as well and of course the very strong presence here in China. So we have known for a long time that autoimmune diseases had a strong genetic basis but we didn't know which mutations caused disease. The challenge and the opportunity now with these new sequencing technologies is to identify the precise mutations that cause disease in each patient. So what we do at the CPI that is unique is that we start with a patient, we find the mutations, we prove that those mutations cause disease, we understand how they cause disease and then we find a therapy and can get back to that patient. So up until now there hasn't been a cure or treatments that are effective and in fact some of the treatments cause serious side effects. What our research is allowing us to do is to start treating some patients with therapies that are very specific and can change their lives and it's our hope that the number of patients that we can treat will continue to increase.