 Inflammatory bowel disease, IBD, is characterized by an abnormal immune response, including two distinct types, Crohn's disease, CD, and ulcerative colitis, UC. Research has revealed that the pathogeny of IBD involves genetic factors, environmental factors, immune dysfunction, dysbiosis, and lifestyle choices. Additionally, patients with IBD exhibit both local and systemic oxidative damage caused by the excessive presence of reactive oxygen species. This oxidative damage exacerbates immune response imbalances, intestinal mucosal damage, and dysbiosis in IBD patients. During the weaning period, pigs' experience pronounced intestinal immune and inflammatory responses, resulting in severe diarrhea and increased mortality rates. Pigs are highly similar to humans in terms of physiology and anatomy, making them a potential choice for simulating human IBD. The exact mechanism behind IBD and post-weaning diarrhea remains unclear, but the oxidative damage, in its progression and pathogenesis, is well-acknowled. This article was authored by Qi Huili, Ting Huizheng, Hanting Ding, and others. We are article.tv, links in the description below.