 Megakaryocyte membrane-wrapped poly, lactic-coglycolic acid, nanoparticles, MKNPs, and chimeric human recombinant factor 8 expressing megakaryoblastic CHRF-288 cells, CHRF-wrapped nanoparticles, CHNPs, are promising vehicles for targeted cargo delivery to hematopoietic stem and progenitor cells, HSPCs. Both MKNPs and CHNPs efficiently targeted and were taken up by HSPCs in vitro and in vivo. This suggests that these vehicles could be used to deliver therapeutics or genetic material to HSPCs for gene therapy applications.