 45S5 based glass products have revolutionized healthcare by bonding to living bone and stimulating osteogenesis through the release of biologically active ions, leading to successful implantation in millions of patients worldwide. Bioactive glasses have many other potential applications in soft tissue repair and drug delivery, and their full potential is yet to be fully realized. The research involving bioactive glasses requires cross-disciplinary collaboration among glass chemists, bioengineers, and clinicians, and the present article provides a picture of current clinical applications while also highlighting six challenges that need to be addressed in the near future. This article was authored by Francesco Baino, Sapita Hamzala, and Saeed Kargozer.