 Vernonia amygdalina, VA, has been traditionally used in Africa as an anti-diabetic remedy. Recently, two active components have been identified from its leaves and roots, luteolin and vernadolol. In this study, the authors investigated the potential of these two compounds to treat diabetes. They found that luteolin had a stronger anti-diabetic effect than vernadolol, but both were effective at reducing blood glucose levels. Luteolin also reduced the formation of ages, which can cause damage to cells and tissues. Additionally, both compounds were able to protect against oxidative stress, which can lead to cell death. These findings suggest that VA may be useful in treating diabetes. This article was authored by Francine Medgio-Facchugio, Valentina Stablam, Alisa Pangratzi, and others.