 This study investigates the role of M7G methylation modifications in lower-grade gliomas, LGGs. It finds that individuals with LGG can be divided into two groups based on their M7G scores which are associated with different clinical outcomes. Additionally, it identifies five potential genetic markers that correlate with the M7G score signature index. This research provides valuable insights into the features and classification associated with M7G methylation modifications which may help improve the clinical outcome of LGG.