 Chronic inflammation caused by biological, chemical, and physical factors has been linked to an increased risk of cancer in various organs. Infectious agents like liver flukes, helicobacter pylori, and human papillomavirus, as well as non-infectious agents like asbestos fibres, have been shown to induce nitric oxide synthase, INOS, dependent formation of eight nitroguanine and 8-oxo-7-8-dihydro-2-deaxoguanicine, 8-oxo-G, in cancer cells and precancerous regions. Our research reveals that these compounds are present in both inflamed and uninflamed areas of cancer tissue, suggesting that DNA-based damage may lead to double-stranded breaks. This is particularly interesting from a genetic stability perspective. Additionally, we observe that phosphorylated ataxia telangiptasia mutated, ATM, and gamma-H2AX were co-localized with 8-oxo-G and 8-nitroguanine in inflammatory cancer tissues, indicating that DNA damage may. This article was authored by Mariko Maota, Rhaeny Thanan, Ninkmaa, and others. We are article.tv, links in the description below.