 This study aims to assess the effectiveness of serious games in alleviating anxiety by summarizing the results of previous studies and providing an up-to-date review. The findings suggest that exogames can be as effective as conventional exercises, computerized cognitive behavioral therapy games and exogames can be more effective than no intervention, and biofeedback games can be more effective than conventional video games. However, the quality of meta-analysed evidence was low, and there were several methodological weaknesses in the individual studies included. Therefore, serious games should be considered complementary to existing interventions, and researchers should use games that are designed specifically to alleviate depression, deliver other therapeutic modalities, and recruit a diverse population of patients with anxiety. This article was authored by Allah ABD Al-Razakh, Mohanad Al-Ajlani, Dari Al-Yawail, and others.