 This research paper examines the similarities between osteosarcoma in humans and dogs, and how it can provide insight into the disease. It found that two genes, interleukin-8, Illinois-8, and solute carrier family-1, glial-high affinity glutamate transporter, member-3, SLC1A3, are expressed in both species, but not in all pediatric osteosarcoma patient samples. Expression of these genes in an independent population of pediatric osteosarcoma patients was associated with poor outcome, P equals 0.020 and P equals 0.026, respectively. This suggests that these genes may play a role in the progression of the disease. Additionally, validation of Illinois-8 and SLC1A3 protein expression in pediatric osteosarcoma tissues further supports the potential value of these novel targets. This article was authored by Trish Timothy, Hewitt-Steven, Picci Piero, and others.