 This study examines the differences between sun-exposed and sun-protected basal cell carcinomas, BCC, in terms of their pathology, prognosis, and clinical features. The results suggest that there may be a correlation between P16 expression and the risk of recurrence in sun-exposed BCCs, but not in sun-protected ones. Additionally, the mean age of patients with sun-exposed BCCs was significantly higher than those with sun-protected ones. This suggests that the biological, prognostic, and clinical aspects of P16 protein expression in BCCs are still far from being clearly understood. This article was authored by Abdul Karim Hassan, Ahmad M. Kando, Hassan S. Al-Gamdi, and others.