(Assuming this is a restart as opposed to a sequel... :D)
Story: When two brothers, Edward and Alphonse Elric tried to revive their mother using Alchemy, something went drastically wrong. Edward lost his leg and his arm, and Alphonse lost his entire body. Now, a few years later, Edward becomes what's known as a "State Alchemist" or a Nationally recognized Alchemist. Along with Alphonse, who's spirit has been put into a metal suit of armor, and his Automail leg and arm, the two brothers set out to find a way to restore themselves.