 This research has developed a new type of substrate made of wood-based cellulose nanofibers that can be used for on-skin electronics. This substrate has been shown to have excellent properties such as skin breathability, skin compatibility, and mechanical endurance. It also has the ability to monitor electroencephalograms, electromigrams, and electrocardiograms, making it ideal for use in medical applications. Additionally, the substrate is reusable, sterile, and environmentally-friendly.