 FAY-based metal phenolic networks, MPNs, are a promising class of nanomaterials that have been extensively studied in the past decade due to their unique properties such as environmental friendliness, high quality, good bioadhesiveness, and biocompatibility. These materials have found wide use in chemodynamic therapy, CDT, and phototherapy, PTT. FAY-based MPNs are commonly used as nanocoding agents to encapsulate drugs or as good fentanyl reagents and photosensitizers to enhance the efficacy of cancer treatments. This review provides an overview of the synthesis methods for FAY-based MPNs, discusses their advantages in CDT and PTT, and outlines potential challenges and opportunities for further development. This article was authored by Weiping Chen, Miao Lu, Han Ping Yang, and others.