 After a long-standing global presence, malaria is now largely non-existent or suppressed in most parts of the world. Today, cases and deaths are primarily concentrated in sub-Saharan Africa. This paper describes the core challenges hindering malaria programs in Africa and highlights key opportunities to rethink current strategies for sustainable control and elimination. This article was authored by Frederiz Okumu, Margaret Jayapong, Nuriya Kasimajana, and others.