 Shift bases are versatile compounds synth-sized from amino and carbonyl compounds, widely used for industrial purposes and exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. They show excellent catalytic activity in various reactions and are useful as catalysts in reactions involving high temperatures. The activity is usually increased by complexation, and the influence of certain metals on their biological activity has prompted a considerable increase in the study of their coordination behavior. Development of new chemotherapeutic shift bases and their metal complexes is attracting the attention of medicinal chemists. This article was authored by Ahmed M. Abu-Dif and Ibrahim M. A. Mohammed.