 This research has developed a novel nanotheraenostic platform that combines two microRNAs, MyRNAs, one that acts as an oncogene and another that acts as a tumor suppressor, to detect low levels of oncogenic MyRNAs and activate suppressor MyRNAs. This platform can be used to detect oncogenic MyRNAs at Fentomolar levels and visualize them inside cells, fixed tissues, and mice. When treated by the oncogenic MyRNA, the platform releases the suppressor MyRNA, which causes a sudden increase in its concentration and a simultaneous decrease in the oncogenic MyRNA. This combination of MyRNAs can then be used to treat tumors with enhanced anti-tumor efficacy and superior biosafety. This article was offered by Xiaoyang, Jia Liu, Li Geizhong, and others.