 This study aims to investigate the relationship between patients' e-health literacy, socio-economic determinants, shared decision-making, SDM, and well-being using data from a multi-center cross-sectional survey in China. The results show that male, highly educated, childless, fully employed, without chronic conditions, and no depressive disorder patients have higher mean scores on the e-health literacy scale, e-heels. Younger patients tend to show higher SSDM. Rural residents and well-paid patients are more likely to report good capability well-being. Patients with a higher SSDM and better capability well-being reported a significantly higher level of e-health literacy than those with lower SSDM and poor capability well-being. The regression models showed a positive relationship between e-health literacy and both SSDM, beta equals 0.22, p less than 0.001, and well-being, beta equals 0.26, p less than 0.001, after adjusting for patients' demographic, socio-economic status, lifestyle, and health status variables. The study concludes that patients with a high level of e-health literacy are more likely to experience optimal SDM and improved capability well-being, but patients' depressive status may alter the relationship between e-health literacy and SSDM. This article was authored by Richard Huan-Su, Ling Ming-Zhou, Eliza Lai-Yu-Wang, and others. We are article.tv, links in the description below.