 This systematic review and meta-analysis aim to assess the effect of a reduction in alcohol consumption on change in blood pressure in adults, stratified by initial amount of alcohol consumption and sex. The study included 36 trials with 2,865 participants and found that a reduction in alcohol intake was associated with increased blood pressure reduction in people who drank more than 2 drinks per day, but not in those who drank 2 or fewer drinks per day. The results suggest that reducing alcohol intake lowers blood pressure in a dose-dependent manner with an apparent threshold effect. Implementation of effective alcohol interventions in people who drink more than 2 drinks per day could reduce the disease burden from both alcohol consumption and hypertension, and should be prioritized in countries with substantial alcohol attributable risk. The study was funded by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health, NE. This article was authored by Dr Michael Roweck, PhD, Professor Janusz Kaczorowski, PhD, Professor Sheldon W. Tope, MD, and others. We are article.tv, links in the description below.