 Fibrates have been shown to be effective in treating bacterial sepsis. They work by preserving the ability of neutrophils to migrate to the site of infection, thus reducing the severity of the systemic inflammatory response. Additionally, they block the activation of ERK, which leads to decreased expression of G-protein coupled receptor kinase II, GPRK II, a key regulator of CXCR II, a chemo-keen receptor essential for neutrophil migration. By blocking this pathway, fibrates prevent the downregulation of CXCR II, allowing neutrophils to continue to migrate to the site of infection and effectively fight off the infection. This article was authored by Ivan Tanchevsky, Manfred Nez, Christina Duensi, and others.