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Published on Feb 19, 2014
Table of Contents: 00:09 Lecture 3.4: Potentiometric Sensors ISFET as a pH-Meter 01:50 Outline 02:54 MOSFET as a pH sensor 09:15 Outline 09:35 Basics of pH control: pH of Pure Water 12:43 Basics of pH Control: Acid/Base 15:29 pH and Surface Charge 16:53 Surface Charging with pH 18:30 Surface Binding Model 21:16 Point of Zero Charge 22:52 Self-consistent surface charge 26:16 Aside: Surface potential and Buffer capacity 28:09 Outline 28:33 Nernst Limit of an Ion Sensitive FET 32:46 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.