 The study investigates the dental changes and space gained following early treatment of pseudo-class 3 malocclusion using a simple fixed appliance in 21 consecutively treated patients with 15 untreated control subjects used as matched controls for a 3-year follow-up. The results show that anterior crossbites and mandibular displacements were eliminated after the treatment, with an average space gain of 4.7 mm in the upper arch, P less than 0.001 degrees. Early treatment provided enough space for eruption of canines and premolars, while lock of space was evident in untreated controls. The study concludes that proclination of upper incisors, leeway space utilization, and arch width increase provided the necessary space for eruption of premolars and canines. This article was authored by Gu Yan and Rabie A. Bakrem.