 peptide neurotoxins found in animal venoms have gained great interest in the field of neurotransmission. As they are high affinity ligands for calcium, potassium, and sodium channels, they have become useful tools for studying channel structure and activity. Peptide neurotoxins represent the clinical potential of ion channel modulators across several therapeutic fields, especially in developing new strategies for treatment of channel-related diseases. The aim of this review is to overview the latest updates in the domain of peptide neurotoxins that affect voltage-gated calcium channels with a special focus on omega agatoxins. This article was authored by Valerie Rowland, Jean Martinez, Michel Veen, and others.