 The study presents a biocompatible and versatile nanoparticle-based platform that delivers calcium ascorbate, VCCA, to cancer cells, enabling combination therapy of hypothermia, ROS generation, and suppression of tumor antioxidant capability. VCCA is released upon photothermal heating, promoting oxidative stress and enhancing any tumor activity. The platform provides a novel paradigm for high-efficiency oxidation photothermal therapy in cancer treatment. This article was authored by Meng Zhong, Xi Ran, Zhu Lingyin, and others.