 Background, substance use is a risk factor for COVID-19 infection and adverse outcomes, but the reasons for elevated risk in substance users are not well understood. The aim of this study was to evaluate whether alcohol or other drug use is associated with adherence to Centers for Disease Control and Prevention, CDC, guidelines for COVID-19 mitigation. Method, a cross-sectional web-based survey was administered to a convenience sample recruited through Amazon's mechanical Turk platform from June 18 to July 19, 2020. Individuals aged 18 years or older and residing in Connecticut, Massachusetts, New Jersey, New York, or Rhode Island were eligible to participate. The exposure of interest was past seven-day use of alcohol, cigarettes, electronic cigarettes, cannabis, stimulants, and non-medical opioids. The primary outcome was CDC guideline at her. This article was authored by Molly A. Monig, Haley Treloar Potovano, Alexander W. Sokolovsky, and others. We are article.tv, links in the description below.