 The study presents a method that enables the docking of different targeting ligands onto the surface of mRNA-loaded small extracellular vesicles, SEVs, using a microfluidic electroporation approach, resulting in immunogenic SEVs, in-ZV, with targeting functionality that preferentially target glioblastoma cells and generate potent antitumor activities in vivo. This article was authored by Xiang Dong, Shen Liu, Yi Bai, and others.