 The long COVID-slash post-acute sequelae of COVID-19, PASC, group includes patients who experience prolonged recovery from their initial mild to moderate symptoms during the acute phase of the illness. These patients often develop new symptoms over several months, such as intermittent fatigue, post-exertional malaise, PEM, CNS symptoms with brain fog, arthralgias, peristegias, dysautonomia, and GI and ophthalmic problems. This suggests that these patients have been affected by a combination of factors, including chronic low-grade inflammation, dysregulation of the brain's microglia, and intermittent fatigue caused by cytokine release. Additionally, there are many similarities between the symptoms of long COVID and myalgic encephalomyelitis-slash-chronic-fatigue syndrome, ME-slash-CFS, suggesting that both conditions could be caused by virally induced epigenetic changes to cytokine gene expression. This article was authored by Russell N. Lowe, Ryan J. Lowe, Ryan J. Lowe, and others.