 The hydrogen evolution reaction, HER, is a half-cell reaction in water electrolysis for producing hydrogen gas. In industrial water electrolysis, the HER is often conducted in alkaline media to achieve higher stability of the electrode materials. However, the kinetics of the HER in alkaline medium is slow relative to that in acid because of the low concentration of protons in the former. Under the latter conditions, the entire HER process will require additional effort to obtain protons by water dissociation near or on the catalyst surface. Heterostructured catalysts with fascinating synergistic effects derived from their heterogeneous interfaces can provide multiple functional sites for the overall reaction process. At present, the activity of the most active known heterostructured catalysts surpasses platinum-based heterostructures or approaches noble metal-free heterostructures that of the commercial point-slash-C catalyst under alkaline conditions demonstrating an infusive potential to break through the bottlenecks. This review summarizes the most representative and recent heterostructured HER catalysts for alkaline medium. This article was authored by Juming Wei, Min Zhou, An Chuan Long, and others. We are article.tv, links in the description below.