 Rheumatoid arthritis is a chronic inflammatory disorder with complex etiopathogenesis, involving multiple endogenous and exogenous factors, including oxidative stress as a critical pathogenic signature. The NRF2 Keep One pathway, a supreme cytoprotective signaling cascade, has been shown to elicit a protective effect against RA and other autoimmune, inflammatory, degenerative disorders. Natural and synthetic antioxidants have been encouraged as additional therapy to conventional drugs for better management of the disease.