 Alfrenylase is a key glycolytic enzyme in the cytoplasm of both procreatic and eukaryotic cells. It is also considered a multifunctional protein, with additional roles including acting as a plasminogen receptor, concentrating proteolytic plasmin activity on the cell surface, and having other cellular functions and subcellular localizations that are distinct from its well-established function in glycolysis. Differential expression of Alfrenylase has been linked to various pathologies, such as cancer, Alzheimer's disease, and rheumatoid arthritis, among others. We have identified Alfrenylase as a plasminogen receptor in several cell types. In particular, we have studied its role in myogenesis as an example of extracellular remodeling process. We have shown that Alfrenylase is expressed on the cell surface of differentiating myocytes, and that inhibitors of Alfrenylase, plasminogen binding block myogenic fusion in vitro and skeletal muscle regeneration in mice. Alpha This article was authored by angels Diaz-Ramos, Ana Roig-Barrellis, Ana Garcia-Milero, and others. We are article.tv, links in the description below.