 Aflatoxins are fungal metabolites found in feeds and foods, which can cause cancer when consumed by ruminants. When aflatoxin B1, AFB1, is metabolized in the rumen of ruminants, it produces aflatoxin M1, AFM1, which is excreted in milk. The International Agency for Research on Cancer, IARC, has classified AFB1 and AFM1 as human carcinogens belonging to group 1 and group 2b, respectively. Recent epidemiological studies have shown that AFB1 and AFM1 exposure can increase the risk of cancer cell proliferation and invasion in cancer patients. In this review, the authors summarized the activation pathways of AFB1 and AFM1 and identify a panel of genes slash proteins slash mirenase that can be used as targets for further studies to evaluate the effects of AFB1 and AFM1 on cancer development and progression. This article was authored by Silvia Marchese, Andrea Polo, Andrea Ariano, and others. We are article.tv, links in the description below.