 The objective evidence suggests that both serum uric acid, SUA, and high-density lipo protein cholesterol, HDLC, are risk factors for chronic kidney disease, CKD, and the SUA to HDLC ratio, UHR, has recently attracted attention as a new biomarker to evaluate the role between inflammatory and anti-inflammatory substances. Our study found that UHR was negatively correlated with estimated glomerular filtration rate, e.g. FR, after adjusting for confounding factors, and participants in the highest quartile of UHR had a higher risk of CKD than those in the lowest quartiles. This suggests that an increased UHR may be a useful measure by which to assess CKD risk in the preclinical stage. This article was authored by Hui Wang, Hao Zhong, Ying Wang, and others.