 Epsilon and its derivatives have been found to be effective inhibitors of the SARS-CoV-2 main proteins, Mpro, and propane-like proteins, PLpro. These compounds have also demonstrated potential as NSP14 inhibitors, with one compound showing particularly strong activity. Additionally, these compounds have been shown to exhibit low cytotoxicity and high antiviral activity. This suggests that they could serve as a basis for developing novel therapeutics for treating COVID-19.