 osteoarthritis is a debilitating degenerative joint disease that affects millions of people worldwide. Advances in fabrication technologies now enable the strategic design of scaffolds with complex, biomimetic structures and properties. In this paper, the design of hybrid and or biomimetic zonal scaffolds for use in articular cartilage tissue engineering is highlighted. This article was authored by Shang Gou Chen, Zarya Zatafar, and William Kulik.