 Pox was diagnosed in two women returning to Vietnam from the United Arab Emirates. The monkeypox viruses belonged to an emerging sub-lineage, a .2.1, distinct from B.1, which is responsible for the ongoing multi-country outbreak. Women could contribute to Pox's transmission and enhanced genomic surveillance is needed to clarify pathogen evolution. This article was authored by Nguyen Thanh Dung, Lu Man Hung, Nguyen Thi Thuy Hoa, and others.