nanoHUB-U Nanobiosensors L3.10: Sensitivity - Cantilever-based Sensors - Basic Operation





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Published on Feb 18, 2014

Table of Contents:
00:09 Lecture 3.10: Cantilever-based Sensors Basic Operation
00:36 Outline
01:38 Three types of sensors
03:38 Mass of molecules
05:40 Why cantilever-based mechanical sensors
07:58 How does a cantilever sensor work
10:49 How to measure deflection
13:02 How to bring the biomolecule to the sensors
14:42 Outline
14:53 Equivalent spring-mass system
17:27 Equivalent spring-mass system
20:47 Oscillation in an ideal spring-mass
23:45 An Example
25:14 Mass only dynamic response: Ideal spring
27:04 Spring-only Dynamic response
28:54 Experimental Validation
29:17 Reversal of frequency at nanoscale
32:38 Composite effects and frequency reversal
34:12 Conclusions

This video is part of the nanoHUB-U course "Principles of Electronic Nanobiosensors".

This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.


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