 Thank you very much and thank you to the Brain Foundation and all its donors for facilitating this research. It's a real honour to be here. So my research is in brain injury as well. I think there's probably very few people in this room who've escaped the current media attention around brain injury and its consequences. So that current media attention suggests that people that experience mild repetitive traumatic brain injury such as that that occurs when they have an impact with someone else in a sporting game or suffer a concussion has lifelong neurodegenerative consequences. In its mildest form they suggest that traumatic brain injury in this form can cause depression and anxiety and that it's worse can cause cognitive deficits that are indistinguishable from Alzheimer's disease and other dementias. The research has come largely from a research group in the states that have been studying American football players that have self-referred because they've been experiencing cognitive problems. And they find a high proportion of those individuals have a neuropathology in their brains that have cellular changes that are known as chronic traumatic encephalopathy. But the research is in its early stages. We don't know enough about whether chronic traumatic encephalopathy causes these clinical symptoms that people are describing. In fact people have reported that the incidence of depression and anxiety is similar in the general population and many of these symptoms are actually similar in the general population. So this grant will allow me to look at chronic traumatic encephalopathy in the large number of cases that I hold in the Sydney Brain Bank for which I'm director of neuroscience research Australia and the University of New South Wales. We want to examine the changes in these brains in these individuals that have been well characterised in life. So we know about their sporting history, we know about the sustained brain injury, we know about their lifestyle factors, whether they consume excessive alcohol, whether they take drugs. We can test their genetics and we can understand the association between TBI traumatic brain injury and chronic traumatic encephalopathy. So we can provide answers not only to the sporting community but at the grassroots level to parents that are worried about their children playing sports.