 Pharmacometric analysis is commonly used to compare the efficacy of different formulations of a given drug. It can also be used to evaluate the bio equivalence of two drugs or drug formulations. Non-compartmental analysis is a popular technique for evaluating the effectiveness of a drug, but it has limitations. Mechanistic compartmental models are more sensitive and provide greater resolution than non-compartmental analysis, making them ideal for assessing the differences between formulations. These models have been successfully applied to two nanomaterial-based formulations, demonstrating their ability to accurately identify differences between formulations. This article was authored by Nidesha Asapova, Andre Budko, Olga Maksimenko, and others.