 Southern unexpected death in children is a tragedy that can leave families searching for answers. Recent advances in genetics have allowed for more accurate diagnoses of certain causes of sudden death, such as primary arrhythmia syndromes. This knowledge has been instrumental in identifying individuals at risk of sudden death and providing them with appropriate medical care. Despite these advancements, however, many cases still remain unexplained. This article was authored by Matthew D. Perry and Jamie Ivandenberg.