 Modern anesthesia is a complex process involving a highly skilled professional who must make quick and accurate decisions in emergencies or planned situations. Additionally, it requires a set of solutions to address any issues that arise. Pharmacological drugs such as anesthetics are used to administer spinal and epidural anesthesia, which are discussed in chronological order. Their origins, inventors and promoters are discussed, along with their potential side effects, indications, dosage and application methods. Recent advances in pain management medication have provided anesthesiologists with more effective options for spinal, epidural and spinal epidural anesthesia. These new drugs offer longer analgesic effects, fewer side effects, less risk of hemodynamic changes and shorter latency periods, allowing them to be recommended for these types of anesthesia. This article was authored by Anyanchikov, AP Marchenko, S.A. Malyanov and others. We are article.tv, links in the description below.