 The COVID-19 pandemic has highlighted the importance of regional collaboration in infectious disease prevention and control. This study examined the literature on regional infectious disease control bodies and networks to identify lessons, barriers and enablers to inform operationalization of a regional infectious disease control body or network in Southeast Asia. Lessons focused on organizational factors, diagnosis and detection, human resources, communication, accreditation, funding and sustainability. Enablers and constraints were consistent across regions slash organizations. A clear understanding of the regional context, budgets, cultural or language issues, staffing capacity and governmental priorities is pivotal. An initial workshop inclusive of the various bodies involved in the design, implementation, monitoring or evaluation of programs is essential. Secure, long-term funding is also a key aspect of the success of any program. This article was authored by Anna Durand-Spagall, Manimur Sukh, Sananda Ugrawal and others. We are article.tv, links in the description below.