 This study assessed the effects of the subcutaneous form of methotrexate, metagect, on the levels of pro-inflammatory cytokines and the morphological characteristics of the carotid arteries in patients with rheumatoid arthritis, RA. The results showed that metagect had a high anti-inflammatory activity and provided a vasoprotective effect on the large vessels of the elastic type, aorta, and common carotid arteries. This suggests that metagect may be beneficial in treating RA. This article was authored by L.A. Niaziva, USETIV, L.A. Niaziva, and others.